Clade C es el subtipo más prevalente de HIV-1 en el mundo. La estructura cristalina del núcleo de clade C gp120 es descrito por Bjorkman y colegas, en conjunto con el complejo CD4 y el receptor CD4 - inducidos por anticuerpo. El trabajo revela que el anticuerpo hace contacto con ambos, gp120 y CD4. La portada de la revista muestra una escultura de vidrio de una partícula viral realizada por el artistaLuke Jerram (http://www.lukejerram.com/projects/glass_microbiology).pp 608–613
Progress stalled on coronavirus
Lack of in-depth studies hampers efforts to identify source.
A year on from the first reported human case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV), the world still has few answers to the most pressing question from a public-health perspective: what is the source of the steady stream of new cases? Only with this information can the outbreak be controlled.
There have so far been 114 confirmed cases of MERS-CoV infection, including 54 deaths, with another 34 suspected cases (see ‘Catching on’). All originated in the Arabian Peninsula, with most in Saudi Arabia and others in Jordan, Qatar and the United Arab Emirates (UAE). Imported cases have occurred in the United Kingdom, France, Italy and Tunisia. The virus is thought to be an animal virus that sporadically jumps to people — there are no signs yet that it can spread easily between humans, although limited spread between people in close contact has been seen.