a switch between peripheral
carbohydrate and lipid utilization
AgRP/NPY neurons are critical regulators of body weight and food intake. Concordant with their orexigenic effects, it is expected that AgRP ablation leads to the appearance of a lean phenotype. In the current issue of The EMBO Journal, Joly-Amado et al (2012) describe an obese phenotype in a model of AgRP-ablated mice, and link it to a shift in metabolic profile in efferent tissues such as the
liver, muscle and pancreas.
liver, muscle and pancreas.
Luis Varela and Tamas L Horvath
The EMBO Journal (2012) 31, 4252–4254.
