ENDOCRINOLOGY

It's in Her Eyes



Crustaceans go through pubertal molt to provide the animal with features that are distinct to adults. The androgenic gland hormone (AGH) is important for male differentiation and secondary male characteristics. Females lack AGH, so are considered the default sex for development. Previous work has shown that when the eyestalk is ablated in the females of some crab species, mating and maternal care structures show defects; however, the animals are able to molt and develop into giant immature crabs. In studying the blue crab, Callinectes sapidus, Zmora et al. now show that the endocrine system and localized activity of a hormone termed crustacean female sex hormone (CFSH) from the eyestalk ganglia are involved in adult-specific development through the control of the pubertal-terminal molt. When CFSH is eliminated, the brooding features, which are important for mating and brooding large clutches, are abnormal. This work shows that the endrocrine system functions via a female-specific hormone for the development of adult morphological structures associated with female reproduction, i.e., for mating and brooding.
Endocrinology 10.1210/en.2013-1603 (2013).
In Science 3 Jan 2014

Striking the right balance with muscle control

Modeling reveals how the central nervous system systematically chooses optimal muscle responses to maintain balance

The central nervous system (CNS) comprises the brain and spinal cord, and coordinates all our bodily activities. One of the functions of the CNS is to choose the most efficient muscle movements in order to conserve energy and allow the body to move smoothly, and it is believed that the CNS trains itself through experience to narrow down the number of options. Fady Alnajjar and colleagues from the Intelligent Behavior Control Unit of the RIKEN Brain Science Institute have now modeled the behavior of muscles during balance tests to illustrate how the human CNS trains itself to maintain balance1.
“Modeling of the computational mechanisms between the CNS and muscle control, which we call muscle synergy, is challenging,” explains Alnajjar. “Our study concerns the muscle synergy behind basic motor skills, such as maintaining balance, in healthy humans.”
Alnajjar’s team developed a model of ‘muscle synergy’ by devising two novel parameters: the synergy stability index (SSI), which measures the similarities between muscle usage in repeated behaviors and therefore the stability of the neural command, and the synergy coordination index, which measures the overall size of the synergy space required to carry out a movement and therefore the level of coordination between muscles.
The researchers used these two parameters to measure the interactions between the human CNS and muscles during balance tests. Eight participants were asked to stand on a randomly moving platform, using only their hips and ankles to maintain balance, with electrodes attached to their major leg and back muscles. 
Both indices were found to successfully characterize the muscle synergy associated with balance skill. “Participants with strong balancing ability showed high SSI levels,” notes Alnajjar, “implying that their CNSs were aware of the best muscle synergy for responding to balance disturbances. Participants with low balancing ability had low SSI levels. Also, good balancers used tightly coordinated muscles, resulting in smoother movements.”
In each case, the CNS appeared to search for a narrow muscle-synergy space of stable neural commands and coordinated muscle reactions. In a second set of experiments using the lowest scorers from round one, each person completed five more sessions on the balance platform. The participants showed significant improvement on completion, suggesting that with training, the CNS can narrow its muscle-synergy space and thus improve coordination.
Alnajjar hopes that an advanced version of these indices could be used to develop therapies for post-stroke motor function recovery as a means of creating targeted, effective neuro-rehabilitation systems.

Como el cerebro escoge la respuesta muscular óptima para mantener el balance estético


El sexo y la pulga de arena

Las pulgas de arena Tunga penetrans pasan la mitad de su vida en la tierra y la otra mitad en un una forma de vida, como por ejemplo un pie humano. Las infestaciones - en América del Sur y África subsahariana - pueden producir una condición dolorosa llamada tungiasis que hace que sea difícil caminar y puede conducir a otras infecciones. Pero la enfermedad ha causado escasa atención por parte de los médicos e investigadores que saben muy poco acerca del ciclo de vida de la criatura, incluso que cuando no está en el suelo tiene sexo y fertiliza sus huevos.

Por eso, cuando Marlene Thielecke, estudiante de doctorado de la Universidad Charité de Berlín, estaba estudiando tungiasis en Madagascar, descubrió que ella misma alojaba al parásito, dejó que su propio cuerpo se convierta en un laboratorio para estudiar la criatura.

La hembra inmadura se entierra en la piel de un hospedero a lo largo de 2 semanas, y se hincha hasta un máximo de 10 mm de diámetro. Pronto empieza expulsar huevos, y muere después de 4 a 6 semanas. La única manera de deshacerse de los parásitos es sacarlos de la piel.

Thielecke tomó fotografías regulares de su infestación. La pulga creció con normalidad, pero no estaba poniendo los huevos. Fue extraño - que todavía estaba vivo después de 2 meses (en ese momento ella la extrajo).

La explicación más probable? La pulga nunca fue fertilizada, Thielecke y su tutor, experto en tungiasis, Hermann Feldmeier, llegaron a esa conclusión en un artículo publicado este mes. En la búsqueda de la pulga, Thielecke había tomado precauciones, usar calcetines y zapatos cerrados para protegerse de otras pulgas, incluyendo potencialmente la fertilización de los machos. Esto sugiere una respuesta al enigma de que las pulgas son fertilizadas después de que se incrustan en la piel . http://scim.ag/fleafert

AMOR EN LA PIEL
















JAMA Dermatol. Dec 2013

QUE SIEMPRE NO EXISTEN LOS HOYOS NEGROS

Stephen Hawking: 'There are no black holes'

Artist's impression VICTOR HABBICK VISIONS/SPL/Getty
The defining characteristic of a black hole may have to give, if the two pillars of modern physics — general relativity and quantum theory — are both correct.

Notion of an 'event horizon', from which nothing can escape, is incompatible with quantum theory, physicist claims.


Most physicists foolhardy enough to write a paper claiming that “there are no black holes” — at least not in the sense we usually imagine — would probably be dismissed as cranks. But when the call to redefine these cosmic crunchers comes from Stephen Hawking, it’s worth taking notice. In a paper posted online, the physicist, based at the University of Cambridge, UK, and one of the creators of modern black-hole theory, does away with the notion of an event horizon, the invisible boundary thought to shroud every black hole, beyond which nothing, not even light, can escape.
In its stead, Hawking’s radical proposal is a much more benign “apparent horizon”, which only temporarily holds matter and energy prisoner before eventually releasing them, albeit in a more garbled form.  

“There is no escape from a black hole in classical theory,” Hawking told Nature. Quantum theory, however, “enables energy and information to escape from a black hole”. A full explanation of the process, the physicist admits, would require a theory that successfully merges gravity with the other fundamental forces of nature. But that is a goal that has eluded physicists for nearly a century. “The correct treatment,” Hawking says, “remains a mystery.”

Hawking posted his paper on the arXiv preprint server on 22 January1. He titled it, whimsically, 'Information preservation and weather forecasting for black holes', and it has yet to pass peer review. The paper was based on a talk he gave via Skype at a meeting at the Kavli Institute for Theoretical Physics in Santa Barbara, California, in August 2013 (watch video of the talk).

Fire fighting

Hawking's new work is an attempt to solve what is known as the black-hole firewall paradox, which has been vexing physicists for almost two years, after it was discovered by theoretical physicist Joseph Polchinski of the Kavli Institute and his colleagues (see 'Astrophysics: Fire in the hole!').
In a thought experiment, the researchers asked what would happen to an astronaut unlucky enough to fall into a black hole. Event horizons are mathematically simple consequences of Einstein's general theory of relativity that were first pointed out by the German astronomer Karl Schwarzschild in a letter he wrote to Einstein in late 1915, less than a month after the publication of the theory. In that picture, physicists had long assumed, the astronaut would happily pass through the event horizon, unaware of his or her impending doom, before gradually being pulled inwards — stretched out along the way, like spaghetti — and eventually crushed at the 'singularity', the black hole’s hypothetical infinitely dense core.

 But on analysing the situation in detail, Polchinski’s team came to the startling realization that the laws of quantum mechanics, which govern particles on small scales, change the situation completely. Quantum theory, they said, dictates that the event horizon must actually be transformed into a highly energetic region, or 'firewall', that would burn the astronaut to a crisp.

This was alarming because, although the firewall obeyed quantum rules, it flouted Einstein’s general theory of relativity. According to that theory, someone in free fall should perceive the laws of physics as being identical everywhere in the Universe — whether they are falling into a black hole or floating in empty intergalactic space. As far as Einstein is concerned, the event horizon should be an unremarkable place.

Beyond the horizon

Now Hawking proposes a third, tantalizingly simple, option. Quantum mechanics and general relativity remain intact, but black holes simply do not have an event horizon to catch fire. The key to his claim is that quantum effects around the black hole cause space-time to fluctuate too wildly for a sharp boundary surface to exist.

In place of the event horizon, Hawking invokes an “apparent horizon”, a surface along which light rays attempting to rush away from the black hole’s core will be suspended. In general relativity, for an unchanging black hole, these two horizons are identical, because light trying to escape from inside a black hole can reach only as far as the event horizon and will be held there, as though stuck on a treadmill. However, the two horizons can, in principle, be distinguished. If more matter gets swallowed by the black hole, its event horizon will swell and grow larger than the apparent horizon.

Conversely, in the 1970s, Hawking also showed that black holes can slowly shrink, spewing out 'Hawking radiation'. In that case, the event horizon would, in theory, become smaller than the apparent horizon. Hawking’s new suggestion is that the apparent horizon is the real boundary. “The absence of event horizons means that there are no black holes — in the sense of regimes from which light can't escape to infinity,” Hawking writes.

“The picture Hawking gives sounds reasonable,” says Don Page, a physicist and expert on black holes at the University of Alberta in Edmonton, Canada, who collaborated with Hawking in the 1970s. “You could say that it is radical to propose there’s no event horizon. But these are highly quantum conditions, and there’s ambiguity about what space-time even is, let alone whether there is a definite region that can be marked as an event horizon.”

Although Page accepts Hawking’s proposal that a black hole could exist without an event horizon, he questions whether that alone is enough to get past the firewall paradox. The presence of even an ephemeral apparent horizon, he cautions, could well cause the same problems as does an event horizon.

Unlike the event horizon, the apparent horizon can eventually dissolve. Page notes that Hawking is opening the door to a scenario so extreme “that anything in principle can get out of a black hole”. Although Hawking does not specify in his paper exactly how an apparent horizon would disappear, Page speculates that when it has shrunk to a certain size, at which the effects of both quantum mechanics and gravity combine, it is plausible that it could vanish. At that point, whatever was once trapped within the black hole would be released (although not in good shape).

If Hawking is correct, there could even be no singularity at the core of the black hole. Instead, matter would be only temporarily held behind the apparent horizon, which would gradually move inward owing to the pull of the black hole, but would never quite crunch down to the centre. Information about this matter would not destroyed, but would be highly scrambled so that, as it is released through Hawking radiation, it would be in a vastly different form, making it almost impossible to work out what the swallowed objects once were.

“It would be worse than trying to reconstruct a book that you burned from its ashes,” says Page. In his paper, Hawking compares it to trying to forecast the weather ahead of time: in theory it is possible, but in practice it is too difficult to do with much accuracy.

Polchinski, however, is sceptical that black holes without an event horizon could exist in nature. The kind of violent fluctuations needed to erase it are too rare in the Universe, he says. “In Einstein’s gravity, the black-hole horizon is not so different from any other part of space,” says Polchinski. “We never see space-time fluctuate in our own neighbourhood: it is just too rare on large scales.”
Raphael Bousso, a theoretical physicist at the University of California, Berkeley, and a former student of Hawking's, says that this latest contribution highlights how “abhorrent” physicists find the potential existence of firewalls. However, he is also cautious about Hawking’s solution. “The idea that there are no points from which you cannot escape a black hole is in some ways an even more radical and problematic suggestion than the existence of firewalls,” he says. "But the fact that we’re still discussing such questions 40 years after Hawking’s first papers on black holes and information is testament to their enormous significance."
Peter van den Berg/Photoshot
 
References
  1. Hawking, S. W. Preprint at http://arxiv.org/abs/1401.5761 (2014).
    Hawking posted his paper on the arXiv preprint server on 22 January1… in article
Nature | News

 

 

SER O NO SER

ESA ES LA CUESTIÓN

Portada de la revista Science del 18 de Octubre de 2013, que nos muestra la caleta completa encontrada en Dmisisi Georgia de un Homo de 1.77 millones de años de edad y que nos recuerda el origen de nuestra humanidad.

OTRA TIERRA Ó Mi OTRO YO



Otra Tierra o Mi otro Yo (Mike Cahill 2011) 
Estupenda propuesta cinematográfica de ciencia ficción, que propone la posibilidad de vidas alternas.

365 DÍAS EN LA CIENCIA EN 2013



FAR OUT

Peer carefully at the lower right of this image and you might just spot the tiny dot that is Earth, seen from more than a billion kilometres away. This vista of Saturn’s famous rings backlit by the Sun was assembled from 141 individual images taken by NASA’s Cassini probe after it moved into Saturn’s shadow in July.

FIRE IN THE SKY

This huge fireball was created by the largest meteor known to hit Earth since the Tunguska rock landed in 1908. Russia was once again the unlucky recipient: the meteor exploded some 30 kilometres above Chelyabinsk in the Urals and shone brighter than the Sun.

BONUS ONLINE-ONLY EDITORS’ CHOICE

Although this image didn’t make our end-of-year print piece, it captivated our selection team. It shows Terry Headley, a volunteer with the University of Minnesota Raptor Center, rescuing an injured bald eagle in April.


365 days: Images of the year http://www.nature.com/news/365-days-images-of-the-year-1.14303

LA PAUSA QUE REFRESCA LA MEMORIA

Ciertos sintomas de la esquizofrenia pueden surgir de la activación incontrolada de neuronas que ayudan a construir recuerdos durante los períodos de descanso.

Mapa de la actividad neuronal durante el descanso, en ratones deficientes de calcineurina. Comparativamente, en los ratones normales, el mapa revela patrones de encendido de neuronal complejos, los cuales están ausentes en el modelo de esquizofrenia de ratón.
© 2013 Susumu Tonegawa, RIKEN–MIT Center for Neural Circuit Genetics

http://www.rikenresearch.riken.jp/eng/research/7553.html

LAS BACTERIAS SABEN DEFENDERSE

Fighting invasion.

When viruses (green) attack bacteria, the bacteria respond with DNA-targeting defenses that biologists have learned to exploit for genetic engineering.


CREDIT: EYE OF SCIENCE/SCIENCE SOURCEScienceVol. 341 no. 6148 pp. 833-836

Brain decoding: Reading minds

By scanning blobs of brain activity, scientists may be able to decode people's thoughts, their dreams and even their intentions.

Anne Hathaway's face appears in a clip from the film Bride Wars, engaged in heated conversation with Kate Hudson. The algorithm confidently labels them with the words 'woman' and 'talk', in large type. Another clip appears — an underwater scene from a wildlife documentary. The program struggles, and eventually offers 'whale' and 'swim' in a small, tentative font.

Brain decoding: Reading minds http://www.nature.com/news/brain-decoding-reading-minds-1.13989

LA COL ROJA


 

¿No es bella?

Progress stalled on coronavirus

Nature | News  

Progress stalled on coronavirus
Lack of in-depth studies hampers efforts to identify source. 


Possible infection with the MERS coronavirus, or a closely related virus, has been detected in camels.
Frank Krahmer/Getty

 A year on from the first reported human case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV), the world still has few answers to the most pressing question from a public-health perspective: what is the source of the steady stream of new cases? Only with this information can the outbreak be controlled.
There have so far been 114 confirmed cases of MERS-CoV infection, including 54 deaths, with another 34 suspected cases (see ‘Catching on’). All originated in the Arabian Peninsula, with most in Saudi Arabia and others in Jordan, Qatar and the United Arab Emirates (UAE). Imported cases have occurred in the United Kingdom, France, Italy and Tunisia. The virus is thought to be an animal virus that sporadically jumps to people — there are no signs yet that it can spread easily between humans, although limited spread between people in close contact has been seen.

Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae

Five European individuals who lived during the Middle Ages provide a look backwards at leprosy

Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have obtained genome sequences of Mycobacterium leprae from skeletons of five medieval leprosy cases from the United Kingdom, Sweden, and Denmark. In one case, the DNA was so well preserved that full de novo assembly of the ancient bacterial genome could be achieved through shotgun sequencing alone. The ancient M. leprae sequences were compared with those of 11 modern strains, representing diverse genotypes and geographic origins. The comparisons revealed remarkable genomic conservation during the past 1000 years, a European origin for leprosy in the Americas, and the presence of an M. leprae genotype in medieval Europe now commonly associated with the Middle East. The exceptional preservation of M. leprae biomarkers, both DNA and mycolic acids, in ancient skeletons has major implications for palaeomicrobiology and human pathogen evolution. 
Science 341, 179 (2013) 

Voyager's Not Gone Yet

La Voyager aún en la Heliosfera

Last summer, it looked like the Voyager 1 spacecraft might have finally reached its ultimate destination. Thirty-five years out from Earth and three times farther from the sun than Pluto, the decrepit spacecraft reported a sharp drop in plasma blowing out from the sun and a sharp jump in cosmic rays streaming in from out in the galaxy.
But three papers published online this week in Science conclude that Voyager 1 has not left the heliosphere—the sun's magnetic bubble inflated by its blowing plasma—and entered interstellar space. That's because Voyager found no accompanying switch from the magnetic field spiraling out from the sun to the magnetic field of interstellar space.
Instead, Voyager has discovered a hybrid part of the heliosphere lying between the heliosphere proper and true interstellar space. And nobody knows how far that hybrid extends and when the spacecraft will actually make humankind's first contact with interstellar space. 

 Science. Volume 340, Number 6140, Issue of 28 June 2013

PLANETA ROSA

Astronomers image pink exoplanet

A magenta exoplanet 17.5 parsecs from Earth is the lowest-mass planet that has ever been directly imaged orbiting a Sun-like star outside the Solar System, NASA announced last week. The Subaru Telescope on Mauna Kea, Hawaii, took pictures of the exoplanet GJ 504b at near-infrared wavelengths with the help of adaptive optics. GJ 504b is four times more massive than Jupiter and, with a surface temperature of 237 °C, still glows pink from its fiery birth 160 million years ago. The rosy planet (pictured in an artist’s impression) orbits the star GJ 504, which can be seen with the naked eye, in the constellation Virgo. With an orbiting radius 43.5 times Earth’s distance from the Sun, GJ 504b challenges current theories of how far away from stars large planets form. The findings will be published in The Astrophysical Journal.

Diverse Crystals Account for Beetle Sheen



Not only are beetles among the most diverse group of animals on Earth, but some rival the most flamboyant birds and dazzling coral reef fish with their metallic sheens. Researchers have now traced the evolutionary history of this iridescence in one group of beetles, the weevils, and identified an unexpectedly varied assortment of complex light-altering crystals in the insects. The new work also shows that these diverse crystal architectures all share a single origin in these beetles' evolutionary past. Weevils "have developed high crystal diversity from a relatively modest tool kit," says Ainsley Seago, a systematist with the Australian National Insect Collection in Canberra, who led the work.

ORIGEN Y EVOLUCION DE LA VIDA.

NUMERO ESPECIAL MONOGRAFICO 
(Hace 16 años)



Cuando platique con el celebre biologo mexicano y del mundo, Toño Lazcano Araujo, de la posibilidad de que nos visitara Stanley Miller, aquel inquieto estudiante graduado de la Universidad de Chicago que había logrado convencer al Doctor Harold Urey de reproducir en una probeta las condiciones que pudo haber tenido la atmósfera primitiva de nuestro planeta, nunca pense en lo grato que resultaría en muchos sentidos.

En primer lugar, en esta casa de trabajo, ARMARIO, todos, especialmente Arturo Chavolla, Cuahtemoc Vite y Maria Luisa Franco me brindaron toda clase de apoyo en relación a la posibiliad de que un suplemento cultural, dedicara, nada menos que todo el número de hoy a un tema que la cultura frecuentemente relega a un segundo o tercer plano o bién ni siquiera considera como importante: La divulgación de un tema científico


En segundo lugar, cuando invité a Javier Ruíz de la Presa a escribir sobre este tema, de inmediato le pareció interesante y hasta estímulante y escribió una colaboración esplendida de la Evolución de la Vida desde “Una perspectiva filosófica”, lo cual une a estas dos partes de la Ciencia la biológica y la humanística, cosa a veces tan dificil de integrar en este fragmentado mundo posmoderno.

Después al hablar con el naturalista jaliscience y Doctor Enrique Estrada Faudon, fué tan amable, que me pareció que la empresa de hacer este número iba a lograrse; Resulta que el Doctor Estrada Faudon es uno de los personajes de las ciencias naturales que ha dado el occidente del país; su experiencia con aspecto juvenil, lo hace imprescindible cuando uno quiere conocer algun aspecto del desarrollo de la Botánica o Geografía del estado de Jalísco. Gracias al Doctor Estrada Faudón presentamos algunas ilustraciones del biólogo mexicano Alfonso L Herrera, que por los años treintas, en plena época cristera, andaba publicando en las mejores revistas francesas los últimos avances de la Biología logrados en su propio laboratorio de la colonia Santa María en la Ciudad de México y en relación con la Plasmogénia o aparición de las primeras formas vivas sobre el planeta.

Por supuesto la aparición de los textos de Miller por un lado y Lazcano por otro, ilustran de manera impecable como la vida sobre la Tierra pudo haber surgido hace unos cuatro mil millones de años y además como esas primeras formas vivas empezaron a desarrollarse, lo cual fué perfectamente captado por JIS en su celebre cartón que dedica en exclusiva a este númeto especial. Precisamente su señor padre el Ingeniero Federico Solorzano, catedrático de “Prehistoria” en el Centro Universitario de Ciencias Sociales y Humanidades, de la Universidad de Guadalajara, nos hace un estupendo recuento de las últimas fases de la evolución: La Evolución de los hominidos precursores del Homo sapiens contemporaneo, discutiendo cuales de los restos arqueológicos de hace unos cien mil años, actualmente encontrados en diversas partes del mundo, corresponde al abuelo del hombre del siglo XXI .

Por último Ulises Iñiguez Mendoza aceptó con amabilidad el reto de colaborar también en este número, desde la perspectiva del cine: Se plantea en su docta colaboración que diferentes cineastas, uno inglés y otro ruso (Kubrick y Tarkovski), de algún modo hicieron una importante incursión en el tema de este número monográfico, por medio de sus obras maestras: 2001: “Una Odisea del Espacio” y “Solaris” respectivamente, demostrando que la cultura es un todo diverso en donde la ciencia y sus ideas permean a todo el actuar humano.

Esperamos que este acontecimiento del número monográfico sea el primero de una serie de números en donde la sociedad intelectual y el ciudadano se enlacen para demostrar que el nivel del periodismo cultural no solo lo constituyen la nota roja y la política sino que también hay sed de ciencia en la comunidad de nuestra región. Enhorabuena. 



PRIMER PLANETA DISTANTE AZUL

First distant planet to be seen in colour is blue

Hubble Space Telescope measures visible light from an exoplanet.


 
  Blue gas giant.- By observing exoplanet HD 189733 b before, during and after it disappeared behind its host star, astronomers were able to discover that its colour is a deep blue. (Artist's impression.)


A navy-blue world orbiting a faraway star is the first exoplanet to have its colour directly measured. Discovered in 2005, HD 189733 b is one of the best-studied planets outside the Solar System, orbiting a star about 19 parsecs away in the Vulpecula, or Fox, constellation. Previous efforts to observe the planet focused on the infrared light it emits — invisible to the human eye.
Last December, astrophysicist Tom Evans at the University of Oxford, UK, and his colleagues used the Hubble Space Telescope to observe the planet and its host star. Hubble's optical resolution is not high enough to actually 'see' the planet as a dot of light separate from its star, so instead, the telescope receives light from both objects that mix into a single point source. To isolate the light contribution of the planet, Evans and his colleagues waited for the planet to move behind the star during its orbit, so that its light would be blocked, and looked for changes in light colour.

Nature News 11 July 2013